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Article

Irf8 exacerbates hypertensive intracerebral hemorrhage by mediating a pro-inflammatory phenotype of microglia through the Stat1/Trim5 axis.

Journal of neuroimmunology - 1 Jun 2026

Wu Jingkun, Hou Liang, Zhu Qinghua, Wang Hongbin, Wang Naizhu

Abstract excerpt

Interferon regulatory factor 8 (Irf8) is a transcription factor expressed only in the microglia in the brain and directs the expression of many genes that serve microglial functions. This report investigates the role of Irf8 in microglia during the progression of hypertensive intracerebral hemorrhage (ICH). L-NAME and angiotensin II initiated the ICH mouse model after stereotactic injection of knockdown and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41780103
DOI: 10.1016/j.jneuroim.2026.578894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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