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Article

A Phenotypic High-Throughput Screen Identifies Small Molecule Modulators of Endogenous RGS10 in BV-2 Cells.

Journal of medicinal chemistry - 28 Nov 2024

Talele Shwetal, Gonzalez Stephanie, Trudeau Julia, Junaid Ahmad, Loy Cody A, Altman Ryan A, Sjögren Benita

Abstract excerpt

Chronic dysregulation of microglial phenotypic balance contributes to prolonged neuroinflammation and neurotoxicity, which is a hallmark of neurodegenerative diseases. Thus, targeting microglial inflammatory signaling represents a promising therapeutic strategy for neurodegenerative diseases. Regulator of G protein Signaling 10 (RGS10) is highly expressed in microglia, where it suppresses pro-inflammatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39547663
DOI: 10.1021/acs.jmedchem.4c01738
PMCID: PMC11613444

Genes

RGS10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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