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Article

IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype.

Cell reports - 19 Apr 2012

Masuda Takahiro, Tsuda Makoto, Yoshinaga Ryohei, Tozaki-Saitoh Hidetoshi, Ozato Keiko, Tamura Tomohiko, Inoue Kazuhide

Abstract excerpt

Microglia become activated by multiple types of damage in the nervous system and play essential roles in neuronal pathologies. However, how microglia transform into reactive phenotypes is poorly understood. Here, we identify the transcription factor interferon regulatory factor 8 (IRF8) as a critical regulator of reactive microglia. Within the spinal cord, IRF8 expression was normally low; however, the expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22832225
DOI: 10.1016/j.celrep.2012.02.014
PMCID: PMC4158926

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