Article
Heterogeneous induction of microglia M2a phenotype by central administration of interleukin-4.
Journal of neuroinflammation - 31 Dec 2014
Pepe Giovanna, Calderazzi Giorgia, De Maglie Marcella, Villa Alessandro Maria, Vegeto Elisabetta
Abstract excerpt
BACKGROUND: Acquisition of the M1 or M2 phenotypes by microglia has been shown to occur during the development of pathological conditions, with M1 activation being widely involved in neurotoxicity in relation with the anatomical localization and the reactivity of subtypes of microglia cells. On the contrary, little is known on the ability of microglia to undergo M2 polarization by interleukin-4 (IL4), the typical...
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