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Article

Ursolic acid promotes microglial polarization toward the M2 phenotype via PPARγ regulation of MMP2 transcription.

Neurotoxicology - 1 May 2023

Wang Yuye, Qiu Luying, Deng Shumin, Liu Fang, He Zhiyi, Li Mengye, Wang Yanzhe

Abstract excerpt

Microglia, which are the primary inflammatory cells of the brain, can undergo phenotypic switching between M1 and M2 polarization, which have opposing effects on inflammation. Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the nuclear receptor family of ligand-inducible transcription factors, and PPARγ is known to regulate M2 macrophage polarization. Previous studies have shown that the...

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PMID: 37019307
DOI: 10.1016/j.neuro.2023.04.001

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