Article
Modulation of microglial phenotypes by dexmedetomidine through TREM2 reduces neuroinflammation in heatstroke.
Scientific reports - 25 Jun 2021
Li Ping, Shen Tingting, Luo Xue, Yang Ju, Luo Zhen, Tan Yulong, He Genlin, Wang Zeze, Yu Xueting, Wang Ying, Yang Xuesen
Abstract excerpt
No FDA approved pharmacological therapy is available to reduce neuroinflammation following heatstroke. Previous studies have indicated that dexmedetomidine (DEX) could protect against inflammation and brain injury in various inflammation-associated diseases. However, no one has tested whether DEX has neuro-protective effects in heatstroke. In this study, we focused on microglial phenotypic modulation to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.