Article
Generalizability of established prostate cancer risk variants in men of African ancestry.
International journal of cancer - 1 Mar 2015
Han Ying, Signorello Lisa B, Strom Sara S, Kittles Rick A, Rybicki Benjamin A, Stanford Janet L, Goodman Phyllis J, Berndt Sonja I, Carpten John, Casey Graham, Chu Lisa, Conti David V, Rand Kristin A, Diver W Ryan, Hennis Anselm J M, John Esther M, Kibel Adam S, Klein Eric A, Kolb Suzanne, Le Marchand Loic, Leske M Cristina, Murphy Adam B, Neslund-Dudas Christine, Park Jong Y, Pettaway Curtis, Rebbeck Timothy R, Gapstur Susan M, Zheng S Lilly, Wu Suh-Yuh, Witte John S, Xu Jianfeng, Isaacs William, Ingles Sue A, Hsing Ann, Easton Douglas F, Eeles Rosalind A, Schumacher Fredrick R, Chanock Stephen, Nemesure Barbara, Blot William J, Stram Daniel O, Henderson Brian E, Haiman Christopher A
Abstract excerpt
Genome-wide association studies have identified more than 80 risk variants for prostate cancer, mainly in European or Asian populations. The generalizability of these variants in other racial/ethnic populations needs to be understood before the loci can be used widely in risk modeling. In our study, we examined 82 previously reported risk variants in 4,853 prostate cancer cases and 4,678 controls of African...
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