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Article

TREM2 and Pain Development: An Old Molecule, a New Target

1 Aug 2025

Abstract excerpt

The essence of pain involves a multi-system interaction encompassing sensation, emotion, and cognition, with multi-level regulatory mechanisms such as peripheral sensitization, central plasticity, neuroimmune signal crosstalk, and glial cell activation playing critical roles. Among these mechanisms, microglia, as the primary immune effector cells in the central nervous system, contribute significantly to chronic...

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PMID: 40842082
DOI: 10.1111/jnc.70188

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