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Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity.

Cell reports - 28 May 2024

Patir Anirudh, Barrington Jack, Szymkowiak Stefan, Brezzo Gaia, Straus Dana, Alfieri Alessio, Lefevre Lucas, Liu Zhaoyuan, Ginhoux Florent, Henderson Neil C, Horsburgh Karen, Ramachandran Prakash, McColl Barry W

Abstract excerpt

Acute stroke triggers extensive changes to myeloid immune cell populations in the brain that may be targets for limiting brain damage and enhancing repair. Immunomodulatory approaches will be most effective with precise manipulation of discrete myeloid cell phenotypes in time and space. Here, we investigate how stroke alters mononuclear myeloid cell composition and phenotypes at single-cell resolution and key...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38762882
DOI: 10.1016/j.celrep.2024.114250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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