Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection.

doi:10.1183/13993003.01667-2022

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Article

Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection.

The European respiratory journal - 1 Jun 2023

Packer Richard J, Shrine Nick, Hall Robert, Melbourne Carl A, Thompson Rebecca, Williams Alex T, Paynton Megan L, Guyatt Anna L, Allen Richard J, Lee Paul H, John Catherine, Campbell Archie, Hayward Caroline, de Vries Maaike, Vonk Judith M, Davitte Jonathan, Hessel Edith, Michalovich David, Betts Joanna C, Sayers Ian, Yeo Astrid, Hall Ian P, Tobin Martin D, Wain Louise V

Abstract excerpt

BACKGROUND: Chronic sputum production impacts on quality of life and is a feature of many respiratory diseases. Identification of the genetic variants associated with chronic sputum production in a disease agnostic sample could improve understanding of its causes and identify new molecular targets for treatment. METHODS: We conducted a genome-wide association study (GWAS) of chronic sputum production in UK...

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Identifiers

PMID: 37263751
DOI: 10.1183/13993003.01667-2022
PMCID: PMC10284065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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