FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses.

doi:10.1038/s41467-020-19814-6

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Article

FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses.

Nature communications - 16 Dec 2020

Ahluwalia Tarunveer S, Eliasen Anders U, Sevelsted Astrid, Pedersen Casper-Emil T, Stokholm Jakob, Chawes Bo, Bork-Jensen Jette, Grarup Niels, Pedersen Oluf, Hansen Torben, Linneberg Allan, Sharma Amitabh, Weiss Scott T, Evans Michael D, Jackson Daniel J, Morin Andreanne, Krogfelt Karen A, Schjørring Susanne, Mortensen Preben B, Hougaard David M, Bybjerg-Grauholm Jonas, Bækvad-Hansen Marie, Mors Ole, Nordentoft Merete, Børglum Anders D, Werge Thomas, Agerbo Esben, Gern James E, Lemanske Robert F, Ober Carole, Pedersen Anders G, Bisgaard Hans, Bønnelykke Klaus

Abstract excerpt

Asthma with severe exacerbation is the most common cause of hospitalization among young children. We aim to increase the understanding of this clinically important disease entity through a genome-wide association study. The discovery analysis comprises 2866 children experiencing severe asthma exacerbation between ages 2 and 6 years, and 65,415 non-asthmatic controls, and we replicate findings in 918 children from...

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Identifiers

PMID: 33328473
DOI: 10.1038/s41467-020-19814-6
PMCID: PMC7744576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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