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Article

T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED.

The European respiratory journal - 1 Feb 2017

Kuo Chih-Hsi Scott, Pavlidis Stelios, Loza Matthew, Baribaud Fred, Rowe Anthony, Pandis Iaonnis, Sousa Ana, Corfield Julie, Djukanovic Ratko, Lutter Rene, Sterk Peter J, Auffray Charles, Guo Yike, Adcock Ian M, Chung Kian Fan

Abstract excerpt

Asthma is characterised by heterogeneous clinical phenotypes. Our objective was to determine molecular phenotypes of asthma by analysing sputum cell transcriptomics from 104 moderate-to-severe asthmatic subjects and 16 nonasthmatic subjects.After filtering on the differentially expressed genes between eosinophil- and noneosinophil-associated sputum inflammation, we used unbiased hierarchical clustering on 508...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28179442
DOI: 10.1183/13993003.02135-2016

Genes

TAC1
TAC3
CCR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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