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Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology

28 Mar 2022

Abstract excerpt

To identify genetic determinants of airway dysfunction, we performed a transcriptome-wide association study for asthma by combining RNA-seq data from the nasal airway epithelium of 681 children, with UK Biobank genetic association data. Our airway analysis identified 95 asthma genes, 58 of which were not identified by transcriptome-wide association analyses using other asthma-relevant tissues. Among these genes...

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PMID: 35347136
DOI: 10.1038/s41467-022-28973-7

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