Article

Genetic Regulators of Sputum Mucin Concentration and Their Associations with COPD Phenotypes

2022-09-28

Abstract excerpt

Hyper-secretion and/or hyper-concentration of mucus is a defining feature of multiple obstructive lung diseases, including chronic obstructive pulmonary disease (COPD). Mucus itself is composed of a mixture of water, ions, salt and proteins, of which the gel-forming mucins, MUC5AC and MUC5B, are the most abundant. Recent studies have linked the concentrations of these proteins in sputum to COPD phenotypes, includi...

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Literature Corpus work: 883ed248-72be-5bf1-b2dd-cb74a4a55d6f
DOI: 10.1101/2022.09.28.509838

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