Article
Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes.
PLoS genetics - 1 Jun 2023
Van Buren Eric, Radicioni Giorgia, Lester Sarah, O'Neal Wanda K, Dang Hong, Kasela Silva, Garudadri Suresh, Curtis Jeffrey L, Han MeiLan K, Krishnan Jerry A, Wan Emily S, Silverman Edwin K, Hastie Annette, Ortega Victor E, Lappalainen Tuuli, Nawijn Martijn C, Berge Maarten van den, Christenson Stephanie A, Li Yun, Cho Michael H, Kesimer Mehmet, Kelada Samir N P
Abstract excerpt
Hyper-secretion and/or hyper-concentration of mucus is a defining feature of multiple obstructive lung diseases, including chronic obstructive pulmonary disease (COPD). Mucus itself is composed of a mixture of water, ions, salt and proteins, of which the gel-forming mucins, MUC5AC and MUC5B, are the most abundant. Recent studies have linked the concentrations of these proteins in sputum to COPD phenotypes,...
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