Article
The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness.
Nature communications - 29 Jun 2022
Reay William R, Geaghan Michael P, Cairns Murray J
Abstract excerpt
Pneumonia remains one of the leading causes of death worldwide. In this study, we use genome-wide meta-analysis of lifetime pneumonia diagnosis (N = 391,044) to identify four association signals outside of the previously implicated major histocompatibility complex region. Integrative analyses and finemapping of these signals support clinically tractable targets, including the mucin MUC5AC and tumour necrosis...
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