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KMT2C-deficient tumors have elevated APOBEC mutagenesis and genomic instability in multiple cancers

29 Jun 2022

Abstract excerpt

Abstract The histone methyltransferase KMT2C is among the most frequently mutated epigenetic modifier genes in cancer and plays an essential role in MRE11-dependent DNA replication fork restart. However, the effects of KMT2C deficiency on genomic instability during tumorigenesis are unclear. Analyzing 9,663 tumors from 30 cancer cohorts, we report that KMT2C mutant tumors have a significant excess of APOBEC...

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PMID: 35898555
DOI: 10.1093/narcan/zcac023

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