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Global identification of MLL2-targeted loci reveals MLL2’s role in diverse signaling pathways

8 Oct 2012

Abstract excerpt

Myeloid/lymphoid or mixed-lineage leukemia (MLL)-family genes encode histone lysine methyltransferases that play important roles in epigenetic regulation of gene transcription. MLL genes are frequently mutated in human cancers. Unlike MLL1, MLL2 (also known as ALR/MLL4) and its homolog MLL3 are not well-understood. Specifically, little is known regarding the extent of global MLL2 involvement in the regulation of...

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PMID: 23045699
DOI: 10.1073/pnas.1208807109

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