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Article

Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application.

Molecular cancer - 6 Apr 2024

Zhang Yuyuan, Xu Mengjun, Ren Yuqing, Ba Yuhao, Liu Shutong, Zuo Anning, Xu Hui, Weng Siyuan, Han Xinwei, Liu Zaoqu

Abstract excerpt

Tertiary lymphoid structures (TLS) are clusters of immune cells that resemble and function similarly to secondary lymphoid organs (SLOs). While TLS is generally associated with an anti-tumour immune response in most cancer types, it has also been observed to act as a pro-tumour immune response. The heterogeneity of TLS function is largely determined by the composition of tumour-infiltrating lymphocytes (TILs) and...

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Identifiers

PMID: 38582847
DOI: 10.1186/s12943-024-01980-6
PMCID: PMC10998345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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