Article

Temporal genomic analysis of melanoma rejection identifies regulators of tumor immune evasion

2023-11-29

Abstract excerpt

Decreased intra-tumor heterogeneity (ITH) correlates with increased patient survival and immunotherapy response. However, even highly homogenous tumors may display variability in their aggressiveness, and how immunologic-factors impinge on their aggressiveness remains understudied. Here we studied the mechanisms responsible for the immune-escape of murine tumors with low ITH. We compared the temporal growth of hom...

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Literature Corpus work: 5d71ce44-6f80-5d81-bc04-b91e93fca278
DOI: 10.1101/2023.11.29.569032

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