Article

Using molecular QTLs to identify cell types and causal variants for complex traits

2018-01-01

Abstract excerpt

Genetic associations have been discovered for many human complex traits, and yet for most associated loci the causal variants and molecular mechanisms remain unknown. Studies mapping quantitative trait loci (QTLs) for molecular phenotypes, such as gene expression, RNA splicing, and chromatin accessibility, provide rich data that can link variant effects in specific cell types with complex traits. These genetic eff...

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Literature Corpus work: c765feed-3251-5016-8502-09c42982fabe
DOI: 10.17863/cam.18288

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