Article
A Novel Next-Generation Sequencing Approach to Detecting Microsatellite Instability and Pan-Tumor Characterization of 1000 Microsatellite Instability-High Cases in 67,000 Patient Samples.
The Journal of molecular diagnostics : JMD - 1 Nov 2019
Trabucco Sally E, Gowen Kyle, Maund Sophia L, Sanford Eric, Fabrizio David A, Hall Michael J, Yakirevich Evgeny, Gregg Jeffrey P, Stephens Phil J, Frampton Garrett M, Hegde Priti S, Miller Vincent A, Ross Jeffrey S, Hartmaier Ryan J, Huang Shih-Min A, Sun James X
Abstract excerpt
Microsatellite instability (MSI) is an important biomarker for predicting response to immune checkpoint inhibitor therapy, as emphasized by the recent checkpoint inhibitor approval for MSI-high (MSI-H) solid tumors. Herein, we describe and validate a novel method for determining MSI status from a next-generation sequencing comprehensive genomic profiling assay using formalin-fixed, paraffin-embedded samples. This...
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