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Microsatellite instability status determined by next-generation sequencing and compared with PD-L1 and tumor mutational burden in 11,348 patients.

Cancer medicine - 1 Mar 2018

Vanderwalde Ari, Spetzler David, Xiao Nianqing, Gatalica Zoran, Marshall John

Abstract excerpt

Microsatellite instability (MSI) testing identifies patients who may benefit from immune checkpoint inhibitors. We developed an MSI assay that uses data from a commercially available next-generation sequencing (NGS) panel to determine MSI status. The assay is applicable across cancer types and does not require matched samples from normal tissue. Here, we describe the MSI-NGS method and explore the relationship of...

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B7-H1 Antigen
Cancer Genomics and Diagnostics
Colorectal Cancer Treatments and Studies
Genetic factors in colorectal cancer
High-Throughput Nucleotide Sequencing

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Microsatellite Instability

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PMID: 29436178
DOI: 10.1002/cam4.1372
PMCID: PMC5852359

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