Article
Immunogenic characteristics of microsatellite instability-low esophagogastric junction adenocarcinoma based on clinicopathological, molecular, immunological and survival analyses.
International journal of cancer - 1 Mar 2021
Imamura Yu, Toihata Tasuku, Haraguchi Ikumi, Ogata Yoko, Takamatsu Manabu, Kuchiba Aya, Tanaka Norio, Gotoh Osamu, Mori Seiichi, Nakashima Yuichiro, Oki Eiji, Mori Masaki, Oda Yoshinao, Taguchi Kenichi, Yamamoto Manabu, Morita Masaru, Yoshida Naoya, Baba Hideo, Mine Shinji, Nunobe Souya, Sano Takeshi, Noda Tetsuo, Watanabe Masayuki
Abstract excerpt
Microsatellite instability (MSI) is categorized by mutation frequency: high MSI (MSI-H), low MSI (MSI-L) and microsatellite stable (MSS). MSI-H tumors have a distinct immunogenic phenotype, with immunotherapies using checkpoint inhibitors already approved for the treatment of MSI-H gastroesophageal adenocarcinoma (GEA); this is not observed for MSI-L or MSS. Here, we tested the hypothesis that MSI-L tumors are...
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