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Article

Large-Scale Cancer Genomic Analysis Reveals Significant Disparities between Microsatellite Instability and Tumor Mutational Burden.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2024

Choi Jungyoon, Park Kyong Hwa, Kim Yeul Hong, Sa Jason K, Sung Hwa Jung, Chen Yu-Wei, Chen Zhishan, Li Chao, Wen Wanqing, Zhang Qingrun, Shu Xiao-Ou, Zheng Wei, Kim Jung Sun, Guo Xingyi

Abstract excerpt

BACKGROUND: Microsatellite instability (MSI) and tumor mutational burden (TMB) are predictive biomarkers for pan-cancer immunotherapy. The interrelationship between MSI-high (MSI-H) and TMB-high (TMB-H) in human cancers and their predictive value for immunotherapy in lung cancer remain unclear. METHODS: We analyzed somatic mutation data from the Genomics Evidence Neoplasia Information Exchange (n = 46,320) to...

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PMID: 38393316
DOI: 10.1158/1055-9965.EPI-23-1466

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ARID1A
ARID1B
IMPACT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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