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Article

Microsatellite instability in cancer: a novel landscape for diagnostic and therapeutic approach.

Archives of toxicology - 1 Oct 2020

Yamamoto Hiroyuki, Watanabe Yoshiyuki, Maehata Tadateru, Imai Kohzoh, Itoh Fumio

Abstract excerpt

Defective DNA mismatch repair creates a strong mutator phenotype, recognized as microsatellite instability (MSI). Various next-generation sequencing-based methods for evaluating cancer MSI status have been established, and NGS-based studies have thoroughly described MSI-driven tumorigenesis. Accordingly, high-frequency MSI (MSI-H) has been detected in 81 tumor types, including those in which MSI was previously...

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Identifiers

PMID: 32632538
DOI: 10.1007/s00204-020-02833-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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