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Homologous recombination repair gene mutations in colorectal cancer favors treatment of immune checkpoint inhibitors.

Molecular carcinogenesis - 1 Sept 2023

Lin Yan, Luo Shanshan, Luo Min, Lu Xuerou, Li Qian, Xie Mingzhi, Huang Yu, Liao Xiaoli, Zhang Yumei, Li Yongqiang, Liang Rong

Abstract excerpt

Immune checkpoint inhibitor (ICI) therapy is insensitive for Colorectal cancer (CRC) patients with microsatellite stable (MSS). Genomic data of three CRC cohort, n = 35), and the Cancer Genome Atlas (TCGA CRC cohort, n = 377), were analyzed. A cohort treated with ICIs from Memorial Sloan Kettering Cancer Center (MSKCC CRC cohort, n = 110) and two cases from the local hospital were characterized the impact of the...

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PMID: 37232365
DOI: 10.1002/mc.23562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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