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DNA Damage Repair Gene Mutations Are Indicative of a Favorable Prognosis in Colorectal Cancer Treated With Immune Checkpoint Inhibitors

19 Feb 2021

Abstract excerpt

BACKGROUND: DNA damage repair (DDR) genes were recently implicated in the anti-tumor immune response. Therefore, it is worthwhile to unravel the implications of DDR pathways in the shaping of immune responsiveness in colorectal cancer (CRC) patients receiving immune checkpoint inhibitors (ICI). METHODS: We analyzed publicly available genomic data from a cohort treated with ICI from Memorial Sloan Kettering Cancer...

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Cancer Immunotherapy and Biomarkers
Ferroptosis and cancer prognosis
PARP inhibition in cancer therapy

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33680909
DOI: 10.3389/fonc.2020.549777

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