Age, sex, and specific gene mutations affect the effects of immune checkpoint inhibitors in colorectal cancer.

doi:10.1016/j.phrs.2020.105028

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Article

Age, sex, and specific gene mutations affect the effects of immune checkpoint inhibitors in colorectal cancer.

Pharmacological research - 1 Sept 2020

Lin Anqi, Zhang Hongman, Hu Xigang, Chen Xiaoting, Wu Gang, Luo Peng, Zhang Jian

Abstract excerpt

The effect of age and sex on the predictive value of colorectal cancer (CRC) patients treated with immune checkpoint inhibitors (ICIs) has been controversial, and the effect of specific gene mutations on the predictive value of CRC patients treated with ICIs remains to be explored. Our study analyzed the influence of the above factors on the overall survival (OS) of CRC patients receiving ICIs and explored the...

Topics

Adenocarcinoma
Age Factors
Aged
Biomarkers, Tumor
Colorectal Neoplasms
Computational Biology
DNA Mutational Analysis
Female
Humans
Immune Checkpoint Inhibitors
Male
Middle Aged
Mutation
Sex Factors
Time Factors

Source

Open in PubMed

Identifiers

PMID: 32569820
DOI: 10.1016/j.phrs.2020.105028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Treatment Outcome

Tumor Microenvironment