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Identification of DNA Repair-related Genes as Biomarkers Reflecting MSI, TMB, and TIL in Colorectal Cancer.

Anticancer research - 1 Aug 2024

Fukuda Junya, Sudo Tomoya, Kikuchi Maako, Kawahara Akihiko, Shigyo Hirona, Kawamoto Yusuke, Shimamura Satoshi, Koga Fumiki, Noguchi Takasi, Nakane Hiroyuki, Shigaki Takahiro, Fujiyoshi Kenji, Yomoda Takato, Yoshida Naohiro, Koushi Kenichi, Yoshida Takefumi, Akiba Jun, Fujita Fumihiko

Abstract excerpt

BACKGROUND/AIM: There are no established biomarkers for immune checkpoint inhibitors (ICI) in colorectal cancer (CRC) with microsatellite stability (MSS) or proficient mismatch repair (pMMR). Therefore, this study aimed to identify biomarkers for ICI benefit in patients with pMMR by analyzing the down-regulated DNA repair-related genes involved in highly immunogenic and immune responses, and comparing their...

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PMID: 39060055
DOI: 10.21873/anticanres.17179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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