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The mutational pattern of homologous recombination-related (HRR) genes in Chinese colon cancer and its relevance to immunotherapy responses.

Aging - 9 Dec 2020

Zhou Pei, Wu Xueying, Chen Huan, Hu Ying, Zhang Henghui, Wu Lijia, Yang Ying, Mao Beibei, Wang Huaqing

Abstract excerpt

BACKGROUND: Microsatellite-stable (MSS) colon adenocarcinoma (COAD) patients are not sensitive to immune checkpoint inhibitors. Here, we focused on analyzing the relationship between homologous recombination repair (HRR)-related gene mutations and clinical immunotherapy responses in MSS COAD. METHODS: The mutational landscape was profiled in a cohort of 406 Chinese COAD patients via next-generation sequencing...

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Identifiers

PMID: 33318301
DOI: 10.18632/aging.202267
PMCID: PMC7880324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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