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Article

Quality control by trans-editing factor prevents global mistranslation of non-protein amino acid α-aminobutyrate.

RNA biology - 1 Jan 2018

Bacusmo Jo Marie, Kuzmishin Alexandra B, Cantara William A, Goto Yuki, Suga Hiroaki, Musier-Forsyth Karin

Abstract excerpt

Accuracy in protein biosynthesis is maintained through multiple pathways, with a critical checkpoint occurring at the tRNA aminoacylation step catalyzed by aminoacyl-tRNA synthetases (ARSs). In addition to the editing functions inherent to some synthetases, single-domain trans-editing factors, which are structurally homologous to ARS editing domains, have evolved as alternative mechanisms to correct mistakes in...

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Identifiers

PMID: 28737471
DOI: 10.1080/15476286.2017.1353846
PMCID: PMC6103672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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