Article
An association of CSF apolipoprotein E glycosylation and amyloid-beta 42 in individuals who carry the APOE4 allele.
Alzheimer's research & therapy - 23 May 2023
Meuret Cristiana J, Hu Yueming, Smadi Sabrina, Bantugan Mikaila Ann, Xian Haotian, Martinez Ashley E, Krauss Ronald M, Ma Qiu-Lan, Nedelkov Dobrin, Yassine Hussein N
Abstract excerpt
Carrying the apolipoprotein E (ApoE) Ɛ4 allele is associated with an increased risk of cerebral amyloidosis and late-onset Alzheimer's disease, but the degree to which apoE glycosylation affects its development is not clear. In a previous pilot study, we identified distinct total and secondary isoform-specific cerebral spinal fluid (CSF) apoE glycosylation profiles, with the E4 isoform having the lowest...
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