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Article

Simple and Fast Assay for Apolipoprotein E Phenotyping and Glycotyping: Discovering Isoform-Specific Glycosylation in Plasma and Cerebrospinal Fluid.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Hu Yueming, Meuret Cristiana, Go Scholastica, Yassine Hussein N, Nedelkov Dobrin

Abstract excerpt

BACKGROUND: The mechanisms of how APOEɛ4 allele (APOE4) increases the risk of Alzheimer's disease (AD) pathology have not been fully elucidated. In cerebrospinal fluid (CSF), apoE is heavily glycosylated. OBJECTIVE: To determine the impact of APOE genotype on the relative abundance of apoE protein isoforms and their specific glycosylation patterns in CSF and plasma via a newly developed mass spectrometric...

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Source

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Identifiers

PMID: 32568201
DOI: 10.3233/JAD-200203
PMCID: PMC7504994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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