Article

Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer’s disease biomarkers

2024-12-20

Abstract excerpt

The apolipoprotein E ( APOE ) ε4 allele is the strongest genetic risk factor for Alzheimer’s disease (AD). ApoE is glycosylated with an O-linked Core-1 sialylated glycan at several sites, yet the impact and function of this glycosylation on AD biomarkers remains unclear. We examined apoE glycosylation in a cohort of cerebrospinal fluid (CSF, n=181) and plasma (n= 178) samples from the Alzheimer’s Disease Neuroima...

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Literature Corpus work: c06cc2c8-bd8a-55ef-97b3-57985a3ef733
DOI: 10.1101/2024.12.20.629619

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