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Article

Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype.

Analytical biochemistry - 1 Jul 2023

Lawler Paige E, Bollinger James G, Schindler Suzanne E, Hodge Cynthia R, Iglesias Nicolas J, Krishnan Vishal, Coulton John B, Li Yan, Holtzman David M, Bateman Randall J

Abstract excerpt

Although the APOE ε4 allele is the strongest genetic risk factor for sporadic Alzheimer's disease (AD), the relationship between apolipoprotein (apoE) and AD pathophysiology is not yet fully understood. Relatively little is known about the apoE protein species, including post-translational modifications, that exist in the human periphery and CNS. To better understand these apoE species, we developed a LC-MS/MS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37072097
DOI: 10.1016/j.ab.2023.115156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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