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Article

The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia.

Scientific reports - 17 May 2023

Budhiparama Nicolaas C, Lumban-Gaol Imelda, Sudoyo Herawati, Magetsari Rahadyan, Wibawa Tri

Abstract excerpt

This study aimed to evaluate the association of SNPs of the IL-1 family with the clinical severity of knee OA. This case‒control study was performed among 100 healthy knees and 130 osteoarthritis (OA) knees of people aged ≥ 50 years with a BMI ≥ 25 kg/m2. The possible correlations among clinical findings, radiographic evaluations, serum levels of IL-1R1 and IL-1Ra, and genotype analyses were evaluated. Three SNPs...

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Source

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Identifiers

PMID: 37198429
DOI: 10.1038/s41598-023-34824-2
PMCID: PMC10192377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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