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Article

Interleukin-1 genetic polymorphisms in knee osteoarthritis: What do we know? A meta-analysis and systematic review.

Journal of orthopaedic surgery (Hong Kong) - 1 Jan 2000

Budhiparama Nicolaas C, Lumban-Gaol Imelda, Sudoyo Herawati, Magetsari Rahadyan, Wibawa Tri

Abstract excerpt

PURPOSE: Interleukin-1 is the main proinflammatory cytokine in osteoarthritis (OA). Several single-nucleotide polymorphisms (SNPs) within the IL-1 gene cluster (IL-1β, IL-1R1, and IL-1RN) have been determined, but their associations with knee OA remain poorly understood. The present study aimed to identify the associations between IL-1 SNPs and knee osteoarthritis. METHODS: This meta-analysis and systematic...

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PMID: 35227123
DOI: 10.1177/23094990221076652

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