Article
IL1B -511(G>A) and IL1RN (VNTR) allelic polymorphisms and susceptibility to knee osteoarthritis in Croatian population.
Rheumatology international - 1 Jul 2012
Jotanovic Zdravko, Etokebe Godfrey Essien, Mihelic Radovan, Kaarvatn Marikken Heiland, Mulac-Jericevic Biserka, Tijanic Tamara, Balen Sanja, Sestan Branko, Dembic Zlatko
Abstract excerpt
Osteoarthritis (OA) is a frequent, destructive joint disease, with debilitating impact on a society regarding medical, social, and economic issues. Although causes of primary OA were still not fully elucidated, evidence points to complex genetic risk that varies among different population groups, including the interleukin-1 (IL-1) gene cluster. Here, we sought to determine allelic and genotypic frequencies of the...
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