Article
Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis.
Osteoarthritis and cartilage - 1 Mar 2011
Kerkhof H J M, Doherty M, Arden N K, Abramson S B, Attur M, Bos S D, Cooper C, Dennison E M, Doherty S A, Evangelou E, Hart D J, Hofman A, Javaid K, Kerna I, Kisand K, Kloppenburg M, Krasnokutsky S, Maciewicz R A, Meulenbelt I, Muir K R, Rivadeneira F, Samuels J, Sezgin M, Slagboom E, Smith A J P, Spector T D, Tamm A, Tamm A, Uitterlinden A G, Wheeler M, Zhai G, Zhang W, van Meurs J B J, Valdes A M
Abstract excerpt
OBJECTIVE: To clarify the role of common genetic variation in the Interleukin-1β (IL1B) and Interleukin-1R antagonist (IL1RN) genes on risk of knee and hip osteoarthritis (OA) and severity of knee OA by means of large-scale meta-analyses. METHODS: We searched PubMed for articles assessing the role of IL1B and IL1RN polymorphisms/haplotypes on the risk of hip and/or knee OA. Novel data were included from eight...
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