Article

The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis

2020-11-04

Abstract excerpt

Pseudomonas aeruginosa is a causative agent in nosocomial infections, notably in ventilated or cystic fibrosis patients. P. aeruginosa isolates expressing the phospholipase ExoU, an effector of the type III secretion system, are the most pathogenic in clinics. Here, using a genome-wide screen, we discovered that ExoU toxicity requires DNAJC5, a host chaperone, to exert its necrotic activity. DNAJC5 is involved in...

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Literature Corpus work: 2655347b-d804-561c-be3e-6d1c7f26e065
DOI: 10.1101/2020.11.04.367706

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