Article

Intrinsic flexibility of Type VII secretion central pore is required for substrate translocation

2026-07-31

Abstract excerpt

<h4>ABSTRACT</h4> Mycobacteria have up to five distinct type VII secretion pathways that play diverse roles in the cell ranging from iron uptake to virulence. To date, high-resolution structures of a hexameric ring-like pore complex have only been determined for closely related mycobacterial ESX-5 systems. The most significant difference between them is the arrangement and flexibility of the inner transmembrane h...

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Literature Corpus work: ad54f495-a64f-54ca-bec4-ee4ea54e451a
DOI: 10.64898/2026.07.31.742005

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