Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of loading and translocation of type VI secretion system effector Tse6.

Nature microbiology - 1 Oct 2018

Quentin Dennis, Ahmad Shehryar, Shanthamoorthy Premy, Mougous Joseph D, Whitney John C, Raunser Stefan

Abstract excerpt

The type VI secretion system (T6SS) primarily functions to mediate antagonistic interactions between contacting bacterial cells, but also mediates interactions with eukaryotic hosts. This molecular machine secretes antibacterial effector proteins by undergoing cycles of extension and contraction; however, how effectors are loaded into the T6SS and subsequently delivered to target bacteria remains poorly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Toxins
Share to Cell Membrane
Share to Cryoelectron Microscopy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lipid Bilayers

Share to Molecular Chaperones

Share to Protein Domains

Share to Protein Stability

Share to Pseudomonas aeruginosa

Source

Open in PubMed Open full text

Identifiers

PMID: 30177742
DOI: 10.1038/s41564-018-0238-z
PMCID: PMC6488228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of loading and translocation of type VI secretion system effector Tse6.PMID 30177742Read ↗

Type VI Secretion Effectors: Methodologies and Biology.Semantic proximity Read ↗

Systematic mutagenesis reveals critical effector functions in the assembly and dueling of the H1-T6SS in <i>Pseudomonas aeruginosa</i>Semantic proximity Read ↗

TssA-TssM-TagA interaction modulates type VI secretion system sheath-tube assembly in Vibrio cholerae.Semantic proximity Read ↗

Three small partner proteins facilitate the type VII-dependent secretion of an antibacterial nucleaseSemantic proximity Read ↗

Bacterial outer membrane vesicles: New insights and applicationsSemantic proximity Read ↗

Type VI secretion system sheath inter-subunit interactions modulate its contraction.Semantic proximity Read ↗

Haemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substrates.Semantic proximity Read ↗

Large-scale discovery of candidate type VI secretion effectors with antibacterial activitySemantic proximity Read ↗

Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis.Semantic proximity Read ↗

Deciphering the structural intricacy in virulence effectors for proton-motive force mediated unfolding and type-III protein secretionSemantic proximity Read ↗

Assembly and mechanisms of bacterial type IV secretion machinesSemantic proximity Read ↗

Shigella hijacks the exocyst to cluster macropinosomes for efficient vacuolar escapeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.