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Article

The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer.

The Journal of pathology - 1 Apr 2012

Ng Charlotte K Y, Cooke Susanna L, Howe Kevin, Newman Scott, Xian Jian, Temple Jillian, Batty Elizabeth M, Pole Jessica C M, Langdon Simon P, Edwards Paul A W, Brenton James D

Abstract excerpt

High-grade serous ovarian carcinoma (HGSOC) is characterized by genomic instability, ubiquitous TP53 loss, and frequent development of platinum resistance. Loss of homologous recombination (HR) is a mutator phenotype present in 50% of HGSOCs and confers hypersensitivity to platinum treatment. We asked which other mutator phenotypes are present in HGSOC and how they drive the emergence of platinum resistance. We...

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Share to BRCA2 Protein
Share to Gene Duplication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homologous Recombination

Share to Neoplasm Grading

Share to Neoplasms, Cystic, Mucinous, and Serous

Share to Platinum Compounds

Share to Tandem Repeat Sequences

Share to Translocation, Genetic

Source

Identifiers

PMID: 22183581
DOI: 10.1002/path.3980

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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