Article

Accuracy of programs for the determination of HLA alleles from NGS data

2017-09-01

Abstract excerpt

The human leukocyte antigen (HLA) genes code for proteins that play a central role in the function of the immune system by presenting peptide antigens to T cells. As HLA genes show extremely high genetic polymorphism, HLA typing on the allele level is demanding and is based on DNA sequencing. Determination of HLA alleles is warranted as many HLA alleles are major genetic factors that confer susceptibility to autoi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 66e8ff17-457f-5d0b-bcac-690e32535035
DOI: 10.1101/183038

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Accuracy of programs for the determination of HLA alleles from NGS dataDOI 10.1101/183038Read

Systematic comparative study of computational methods for HLA typing from next-generation sequencing.Semantic proximity Read

Benchmark of tools for in silico prediction of MHC class I and class II genotypes from NGS data.Semantic proximity Read

Benchmarking freely available human leukocyte antigen typing algorithms across varying genes, coverages and typing resolutionsSemantic proximity Read

Benchmark of tools for in silico prediction of MHC class I and class II genotypes from NGS dataSemantic proximity Read

Bioinformatics Strategies, Challenges, and Opportunities for Next Generation Sequencing-Based HLA GenotypingSemantic proximity Read

HLA-HD: An accurate HLA typing algorithm for next-generation sequencing data.Semantic proximity Read

Benchmark of tools for <i>in silico</i> prediction of MHC class I and class II genotypes from NGS dataSemantic proximity Read

HLA typing from 1000 genomes whole genome and whole exome illumina data.Semantic proximity Read

NovAT tool-Reliable novel HLA alleles identification from next-generation sequencing data.Semantic proximity Read

Comprehensive HLA Typing from a Current Allele Database Using Next-Generation Sequencing Data.Semantic proximity Read

Evaluation of computational programs to predict HLA genotypes from genomic sequencing data.Semantic proximity Read

Benchmarking the HLA typing performance of three HLA assays and seven NGS-based HLA algorithmsSemantic proximity Read