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Article

Curcumin inhibits liquid-liquid phase separation of fused in sarcoma and attenuates the sequestration of pyruvate kinase to restore cellular metabolism.

Food & function - 22 May 2023

Shi Wen-Pu, Lin Wen-Juan, Ge Wan-Yi, Chen Liang-Liang, Zhang Tuo-Di, Guo Wei-Hong, Liu Jian-Li, Yin Da-Chuan

Abstract excerpt

The abnormal accumulation of fused in sarcoma (FUS) is a pathological hallmark in a proportion of patients with frontotemporal dementia and amyotrophic lateral sclerosis. Therefore, the clearance of FUS aggregates is a possible therapeutic strategy for FUS-associated neurodegenerative diseases. This study reports that curcumin can strongly suppress FUS droplet formation and stress granule aggregation of FUS....

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Identifiers

PMID: 37158592
DOI: 10.1039/d2fo03224d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Curcumin inhibits liquid-liquid phase separation of fused in sarcoma and attenuates the sequestration of pyruvate kinase to restore cellular metabolism.PMID 37158592Read ↗

The prion-like domain of Fused in Sarcoma is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions.Semantic proximity Read ↗

The prionlike domain of FUS is multiphosphorylated following DNA damage without altering nuclear localizationSemantic proximity Read ↗

Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s diseaseSemantic proximity Read ↗

ATP enhances at low concentrations but dissolves at high concentrations liquid-liquid phase separation (LLPS) of ALS/FTD-causing FUS.Semantic proximity Read ↗

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.Semantic proximity Read ↗

Fused in Sarcoma: Properties, Self-Assembly and Correlation with Neurodegenerative DiseasesSemantic proximity Read ↗

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid–liquid phase separationSemantic proximity Read ↗

Droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show slower inner fluiditySemantic proximity Read ↗

Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration.Semantic proximity Read ↗

Phase-Separated Biomolecular Condensation in Cancer: New Horizons and Next Frontiers.Semantic proximity Read ↗

Protein thiol alterations drive aberrant phase separation in agingSemantic proximity Read ↗

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separationSemantic proximity Read ↗

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