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Article

ATP enhances at low concentrations but dissolves at high concentrations liquid-liquid phase separation (LLPS) of ALS/FTD-causing FUS.

Biochemical and biophysical research communications - 2 Oct 2018

Kang Jian, Lim Liangzhong, Song Jianxing

Abstract excerpt

ATP is the universal energy currency but mysteriously its cellular concentration is much higher than that needed for providing energy. Recently ATP was decoded to act as a hydrotrope to dissolve liquid-liquid phase separation (LLPS) of FUS whose aggregation leads to ALS/FTD. By DIC microscopy and NMR, here we characterized the effect of ATP on LLPS of FUS and its N-/C-terminal domains. Very unexpectedly, we found...

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Identifiers

PMID: 30205960
DOI: 10.1016/j.bbrc.2018.09.014

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