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Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease

14 Sept 2023

Abstract excerpt

Parkinson's disease (PD) is the second most common neurodegenerative disease in the world, and alpha-synuclein (α-syn) abnormal aggregate and mitochondrial dysfunction play a crucial role in its pathological development. Recent studies have revealed that proteins can form condensates through liquid-liquid phase separation (LLPS), and LLPS has been found to be widely present in α-syn aberrant aggregate and...

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PMID: 37781241
DOI: 10.3389/fnins.2023.1250532

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