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Article

The prionlike domain of FUS is multiphosphorylated following DNA damage without altering nuclear localization

13 Jun 2018

Abstract excerpt

FUS (fused in sarcoma) is an abundant, predominantly nuclear protein involved in RNA processing. Under various conditions, FUS functionally associates with RNA and other macromolecules to form distinct, reversible phase-separated liquid structures. Persistence of the phase-separated state and increased cytoplasmic localization are both hypothesized to predispose FUS to irreversible aggregation, which is a...

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PMID: 29897835
DOI: 10.1091/mbc.e17-12-0735

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