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Article

Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration.

The Journal of biological chemistry - 1 Aug 2022

Kishino Yuya, Matsukawa Koji, Matsumoto Taisei, Miyazaki Ryota, Wakabayashi Tomoko, Nonaka Takashi, Kametani Fuyuki, Hasegawa Masato, Hashimoto Tadafumi, Iwatsubo Takeshi

Abstract excerpt

Aberrant cytoplasmic accumulation of an RNA-binding protein, fused in sarcoma (FUS), characterizes the neuropathology of subtypes of ALS and frontotemporal lobar degeneration, although the effects of post-translational modifications of FUS, especially phosphorylation, on its neurotoxicity have not been fully characterized. Here, we show that casein kinase 1δ (CK1δ) phosphorylates FUS at 10 serine/threonine...

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Identifiers

PMID: 35753345
DOI: 10.1016/j.jbc.2022.102191
PMCID: PMC9293781

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Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration.PMID 35753345Read ↗

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